As of April 2020 there were no therapies or vaccine for the coronavirus, despite years of warnings about bat-borne coronaviruses.
Resolved true The record shows it happened or was so.
Factual: Statements about the present or the past, checked against the record: did they hold up?
The second judge said mostly true; the verdict shown is the first judge's.
Said for an organisation they lead or work for; it counts on both records.
What would count as true or false
True: as of 2020-04-18 no approved or proven therapy and no vaccine existed for COVID-19 (SARS-CoV-2), and there had been documented scientific warnings over earlier years (for example, after SARS in 2003 and in bat-coronavirus research published from about 2005 to 2019) about the pandemic risk from bat-borne coronaviruses. Mostly true: both points hold in substance but a detail is off, for example drugs were in use under emergency or compassionate-use authorisation without proven benefit. Mixed: one of the two parts (no therapies/vaccine, or years of warnings) holds and the other does not. Mostly false: a proven, approved therapy did exist, or the warnings were far weaker or more obscure than the claim suggests. False: an approved vaccine or proven therapy existed by that date and there were no prior warnings.
Set before the research began.
Evidence (4)
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E1 Broad anti-coronaviral activity of FDA approved drugs against SARS-CoV-2 in vitro and SARS-CoV in vivo bioRxiv (preprint) · 27 April 2020
“There are no FDA approved antivirals or vaccines for any coronavirus, including SARS-CoV-2. Current treatments for COVID-19 are limited to supportive therapies and off-label use of FDA approved drugs.”
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E2 Broad anti-coronaviral activity of FDA approved drugs against SARS-CoV-2 in vitro and SARS-CoV in vivo bioRxiv (preprint) · 27 April 2020
“Since the emergence of SARS-CoV in 2002, research has uncovered many details of coronavirus biology and pathogenesis, however there are currently no approved therapeutics against this emerging virus family.”
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E3 A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence - Nature Medicine Nature Medicine · 9 November 2015
“Our work suggests a potential risk of SARS-CoV re-emergence from viruses currently circulating in bat populations.”
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E4 A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence - Nature Medicine Nature Medicine · 9 November 2015
“Evaluation of available SARS-based immune-therapeutic and prophylactic modalities revealed poor efficacy; both monoclonal antibody and vaccine approaches failed to neutralize and protect from infection with CoVs using the novel spike protein.”
Reasoning
A preprint dated nine days after the claim says there were no FDA-approved antivirals or vaccines for any coronavirus, including SARS-CoV-2. It says treatment was limited to supportive care and off-label use of approved drugs, so no approved or proven therapy existed (E1, E2). A 2015 Nature Medicine paper warned of a potential risk of SARS-CoV re-emergence from coronaviruses circulating in bats (E3). It also found that existing SARS-based antibody and vaccine approaches did not protect against the novel bat coronavirus spike (E4). That is a documented warning made years earlier, in a 2015 paper [E3]; with no approved therapy or vaccine reported [E1][E2], though E1 also notes off-label use of approved drugs, both parts of the claim hold in substance under the criteria.
Cite this claim
Marc Andreessen, “As of April 2020 there were no therapies or vaccine for the coronavirus, despite years of warnings about bat-borne coronaviruses.” (said 18 April 2020). Verdict: resolved true. Reliability API, claim c_28e45d92c008, method 0.1.0+c876030c, dataset release v1.1.2. https://epistacklabs.com/claims/c_28e45d92c008
This claim is in dataset release v1.1.2, with the same verdict.
Reply to this claim
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Verdicts are made automatically; how verdicts are made.